Stocks to Watch: Barnes & Noble, Gen-Probe (Update 1)

Updated with information about Barnes & Noble's deal with Microsoft, Hologic's acquisition of Gen-Probe.

NEW YORK -- Microsoft(MSFT) will make a $300 million investment for a 17.6% stake in a new Barnes & Noble(BKS) subsidiary that will bring together the bookseller's digital and college businesses.

The partnership includes a NOOK application for Windows 8, Barnes & Noble and Microsoft said.

Shares of Barnes & Noble soared 72.08% in premarket trading Monday to $23.54. The stock has fallen 5.52% year to date.

Microsoft shares ticked up 21 cents, or 0.66%, in premarket trading to $32.19. The stock has risen 23.19% year to date.

Hologic(HOLX) agreed to acquire Gen-Probe(GPRO) for $82.75 a share in a cash, or about $3.7 billion..

Shares of Gen-Probe rose 19.33% in premarket trading Monday to $82. The stock has risen 16.23% year to date.

Hologic shares increased 4.8% in premarket trading to $22.25. The stock has gained 21.25% year to date.

NYSE Euronext (NYX) said first-quarter adjusted earnings declined 32%.

The exchange saw a slowdown in trading, particularly in its derivatives trading unit, and was hit by costs associated with its failed merger with Germany's Deutsche Boerse.

Adjusted profit in the quarter was 47 cents a share; analysts were looking for 48 cents.

Humana(HUM) , the health care company, reported first-quarter earnings Monday of $248 million, or $1.49 a share, down from year-earlier earnings of $315 million, or $1.86 a share.

First-quarter earnings included a gain of 3 cents a share from previous medical claim reserves; year-earlier earnings included a gain of 31 cents a share.

Humana was expected by analysts to report first-quarter earnings of $1.52 a share.

Humana raised its full-year 2012 guidance to between $7.55 a share and $7.75 a share from a previous range of between $7.50 a share and $7.70 a share. Analysts were calling for earnings of $7.99 a share.